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Protagonist Therapeutics Inc (NASDAQ: PTGX) closed the day trading at $77.68 up 0.96% from the previous closing price of $76.94. In other words, the price has increased by $0.96 from its previous closing price. On the day, 1.15 million shares were traded. PTGX stock price reached its highest trading level at $78.15 during the session, while it also had its lowest trading level at $75.29.
Ratios:
For a better understanding of PTGX, let’s look at its different ratios. It provided that stocks Price–to–Cash (P/C) ratio for the trailing twelve months (TTM) is standing at 8.47 whereas its Price-to-Free Cash Flow (P/FCF) for the term is 130.26. For the most recent quarter (mrq), Quick Ratio is recorded 16.97 and its Current Ratio is at 16.97. In the meantime, Its Debt-to-Equity ratio is 0.02 whereas as Long-Term Debt/Eq ratio is at 0.01.
Upgrades & Downgrades
In addition, analysts’ ratings and any changes thereto give investors an idea of. The stock’s future direction. In the most recent recommendation for this company, Barclays on September 17, 2025, initiated with a Overweight rating and assigned the stock a target price of $72.
On September 12, 2025, Leerink Partners started tracking the stock assigning a Outperform rating and target price of $73.
On June 17, 2025, Citigroup started tracking the stock assigning a Buy rating and target price of $72.Citigroup initiated its Buy rating on June 17, 2025, with a $72 target price.
Insider Transactions:
The insider trade also gives investors a glimpse into the future direction of stock prices, which can be beneficial to investors. A recent insider transaction in this stock occurred on Oct 10 ’25 when Waddill William D. sold 12,000 shares for $81.62 per share. The transaction valued at 979,480 led to the insider holds 5,130 shares of the business.
WILLIAM WADDILL bought 12,000 shares of PTGX for $804,480 on Oct 10 ’25. On Sep 22 ’25, another insider, Waddill William D., who serves as the Director of the company, sold 4,000 shares for $64.25 each. As a result, the insider received 257,000 and left with 5,130 shares of the company.
Valuation Measures:
Investors should consider key stock statistics when deciding whether to invest or divest. In the wake of the recent closing price, PTGX now has a Market Capitalization of 4832575488 and an Enterprise Value of 4273389056. As of this moment, Protagonist’s Price-to-Earnings (P/E) ratio for their current fiscal year is 109.01. For the stock, the TTM Price-to-Sale (P/S) ratio is 23.10 while its Price-to-Book (P/B) ratio in mrq is 7.22. Its current Enterprise Value per Revenue stands at 20.429 whereas that against EBITDA is 171.843.
Stock Price History:
The Beta on a monthly basis for PTGX is 2.18, which has changed by 0.636325 over the last 52 weeks, in comparison to a change of 0.14201736 over the same period for the S&P500. Over the past 52 weeks, PTGX has reached a high of $93.25, while it has fallen to a 52-week low of $33.31. The 50-Day Moving Average of the stock is 26.48%, while the 200-Day Moving Average is calculated to be 55.05%.
Shares Statistics:
Over the past 3-months, PTGX traded about 1.04M shares per day on average, while over the past 10 days, PTGX traded about 2047720 shares per day. A total of 62.11M shares are outstanding, with a floating share count of 58.74M. Insiders hold about 5.58% of the company’s shares, while institutions hold 110.92% stake in the company. Shares short for PTGX as of 1759190400 were 6641782 with a Short Ratio of 6.38, compared to 1756425600 on 6846871. Therefore, it implies a Short% of Shares Outstanding of 6641782 and a Short% of Float of 12.8.
Earnings Estimates
As of right now, 9.0 analysts gave their recommendation on the stock of the company. The consensus estimate for the next quarter is -$0.61, with high estimates of -$0.47 and low estimates of -$0.75.
Analysts are recommending an EPS of between -$1.53 and -$2.83 for the fiscal current year, implying an average EPS of -$2.02. EPS for the following year is -$0.63, with 9.0 analysts recommending between $3.41 and -$3.69.
Revenue Estimates
A total of 12 analysts have provided revenue estimates for PTGX’s current fiscal year. The highest revenue estimate was $258.9M, while the lowest revenue estimate was $33.87M, resulting in an average revenue estimate of $63.56M. In the same quarter a year ago, actual revenue was $434.43M
