Investor’s Toolkit: Key Ratios for Assessing Alnylam Pharmaceuticals Inc (ALNY)’s Performance

Kevin Freeman

In the journey to outperform the market, investors delve into the art of stock selection. Choosing the right stocks can be a powerful driver for wealth accumulation.

Alnylam Pharmaceuticals Inc (NASDAQ: ALNY) closed the day trading at $434.23 down -0.49% from the previous closing price of $436.38. In other words, the price has decreased by -$0.49 from its previous closing price. On the day, 1.73 million shares were traded. ALNY stock price reached its highest trading level at $444.67 during the session, while it also had its lowest trading level at $420.3454.

Ratios:

For a better understanding of ALNY, let’s look at its different ratios. It provided that stocks Price–to–Cash (P/C) ratio for the trailing twelve months (TTM) is standing at 21.06 whereas its Price-to-Free Cash Flow (P/FCF) for the term is 259.16. For the most recent quarter (mrq), Quick Ratio is recorded 2.49 and its Current Ratio is at 2.54. In the meantime, Its Debt-to-Equity ratio is 11.86 whereas as Long-Term Debt/Eq ratio is at 11.17.

On August 04, 2025, Oppenheimer Upgraded its rating to Outperform which previously was Perform but kept the price unchanged to $490.

Insider Transactions:

The insider trade also gives investors a glimpse into the future direction of stock prices, which can be beneficial to investors. A recent insider transaction in this stock occurred on Nov 17 ’25 when Fitzgerald Kevin Joseph sold 12,128 shares for $452.18 per share. The transaction valued at 5,483,990 led to the insider holds 21,264 shares of the business.

Fitzgerald Kevin Joseph bought 12,128 shares of ALNY for $5,445,472 on Nov 17 ’25. On Nov 12 ’25, another insider, Greenstreet Yvonne, who serves as the Chief Executive Officer of the company, sold 15,650 shares for $453.69 each. As a result, the insider received 7,100,322 and left with 65,409 shares of the company.

Valuation Measures:

Investors should consider key stock statistics when deciding whether to invest or divest. In the wake of the recent closing price, ALNY now has a Market Capitalization of 57367785472 and an Enterprise Value of 57416466432. As of this moment, Alnylam’s Price-to-Earnings (P/E) ratio for their current fiscal year is 1806.28, and their Forward P/E ratio for the next fiscal year is 58.10. For the stock, the TTM Price-to-Sale (P/S) ratio is 17.87 while its Price-to-Book (P/B) ratio in mrq is 244.67. Its current Enterprise Value per Revenue stands at 17.886 whereas that against EBITDA is 178.856.

Stock Price History:

The Beta on a monthly basis for ALNY is 0.32, which has changed by 0.7224393 over the last 52 weeks, in comparison to a change of 0.09654534 over the same period for the S&P500. Over the past 52 weeks, ALNY has reached a high of $495.55, while it has fallen to a 52-week low of $205.87. The 50-Day Moving Average of the stock is -4.94%, while the 200-Day Moving Average is calculated to be 24.09%.

Shares Statistics:

Over the past 3-months, ALNY traded about 1.08M shares per day on average, while over the past 10 days, ALNY traded about 903590 shares per day. A total of 131.79M shares are outstanding, with a floating share count of 129.75M. Insiders hold about 1.79% of the company’s shares, while institutions hold 99.34% stake in the company. Shares short for ALNY as of 1761868800 were 3769098 with a Short Ratio of 3.48, compared to 1759190400 on 3507540. Therefore, it implies a Short% of Shares Outstanding of 3769098 and a Short% of Float of 3.75.

Earnings Estimates

. The current assessment of Alnylam Pharmaceuticals Inc (ALNY) involves the perspectives of 11.0 analysts closely monitoring its market dynamics.The consensus estimate for the next quarter is $2.09, with high estimates of $2.55 and low estimates of $1.55.

Analysts are recommending an EPS of between $5.99 and $3.76 for the fiscal current year, implying an average EPS of $4.96. EPS for the following year is $10.61, with 12.0 analysts recommending between $13.86 and $6.44.

Revenue Estimates

20 analysts predict $1.17B in revenue for. The current quarter. It ranges from a high estimate of $1.61B to a low estimate of $1.04B. As of. The current estimate, Alnylam Pharmaceuticals Inc’s year-ago sales were $593.17MFor the next quarter, 20 analysts are estimating revenue of $1.22B. There is a high estimate of $1.31B for the next quarter, whereas the lowest estimate is $1.11B.

A total of 24 analysts have provided revenue estimates for ALNY’s current fiscal year. The highest revenue estimate was $4.23B, while the lowest revenue estimate was $3.42B, resulting in an average revenue estimate of $3.74B. In the same quarter a year ago, actual revenue was $2.25BBased on 23 analysts’ estimates, the company’s revenue will be $5.33B in the next fiscal year. The high estimate is $6.12B and the low estimate is $4.34B.

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