Metric Deep Dive: Understanding Upstream Bio Inc (UPB) Through its Ratios

Kiel Thompson

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After finishing at $26.97 in the prior trading day, Upstream Bio Inc (NASDAQ: UPB) closed at $27.74, up 2.86%. In other words, the price has increased by $2.86 from its previous closing price. On the day, 0.57 million shares were traded. UPB stock price reached its highest trading level at $28.45 during the session, while it also had its lowest trading level at $26.69.

Ratios:

Our goal is to gain a better understanding of UPB by taking a closer look at its different ratios. For the most recent quarter (mrq), Quick Ratio is recorded 32.67 and its Current Ratio is at 32.67. In the meantime, Its Debt-to-Equity ratio is 0.00 whereas as Long-Term Debt/Eq ratio is at 0.00.

Upgrades & Downgrades

In the most recent recommendation for this company, Evercore ISI on November 18, 2025, initiated with a Outperform rating and assigned the stock a target price of $40.

On October 14, 2025, Truist started tracking the stock assigning a Buy rating and target price of $47.

Valuation Measures:

Investors should consider key stock statistics when deciding whether to invest or divest. In the wake of the recent closing price, UPB now has a Market Capitalization of 1499030528 and an Enterprise Value of 1128022528. For the stock, the TTM Price-to-Sale (P/S) ratio is 535.37 while its Price-to-Book (P/B) ratio in mrq is 3.96. Its current Enterprise Value per Revenue stands at 403.009 whereas that against EBITDA is -8.038.

Stock Price History:

The Beta on a monthly basis for UPB is 1.94, which has changed by 0.13129199 over the last 52 weeks, in comparison to a change of 0.12469888 over the same period for the S&P500. Over the past 52 weeks, UPB has reached a high of $29.89, while it has fallen to a 52-week low of $5.14. The 50-Day Moving Average of the stock is 20.85%, while the 200-Day Moving Average is calculated to be 93.17%.

Shares Statistics:

The stock has traded on average 443.78K shares per day over the past 3-months and 555830 shares per day over the last 10 days, according to various share statistics. A total of 54.00M shares are outstanding, with a floating share count of 25.64M. Insiders hold about 52.55% of the company’s shares, while institutions hold 56.55% stake in the company. Shares short for UPB as of 1763078400 were 2994056 with a Short Ratio of 6.75, compared to 1760486400 on 3336913. Therefore, it implies a Short% of Shares Outstanding of 2994056 and a Short% of Float of 9.99.